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Research Area 

Plumbline is applying the DNA medicine platform technology to develop both companion animal therapeutics and farm animal vaccines.
  • Dog Cancer

  • Farm animal infectious diseases

  • Telomerase Reverse Transcriptase (TERT) is a protein that is required for cancer cells to multiply constantly.
    The product we are developing consists of TERT DNA, which is specialized for dog breeds, and is injected into the body to produce immunity against TERT. After that, the immune cells in the body recognize TERT of cancer cells as an antigen and attack cancer cells. In mouse and monkey experiments, a strong cellular immune response results in delaying the tumor growths, and increasing the survival rate.

    The PLS-D5000 vaccine is a cancer prevention and treatment for dogs. Our initial goal is to penetrate the US market which is the largest for companion animals in the world. By providing less invasive and more affordable drug, PLS-D5000 will be focusing on the market for dog cancer treatments which provides very little options at very high prices.
    Plumbline Life Sciences Inc. plans to explore options such as licensing agreements and partnerships in the future.





  • Foot and Mouth Disease (FMD) is a highly infectious viral disease that attacks cloven-hoofed animals and was identified as the first animal infectious disease by the World Organization for Animal Health (OIE). We are developing a DNA vaccine to prevent this disease. In addition, we are developing DNA vaccines specialized for viral infectious diseases such as Porcine Reproductive and Respiratory Syndrome (PRRS) and Porcine Epidemic Diarrhea (PED). These vaccines are currently under study.

  • Age-related immune deficiency in senior dogs

  • Farm animal Immune modulators

  • Growth Hormone Releasing Hormone is one of the naturally occurring hormones in the body and plays an important role not only in the growth of the organism, but also in the regulation of the metabolism and immune system.
    We are developing therapeutic agents using GHRH DNA plasmids, which are designed to be optimal for each animal species. Injecting GHRH DNA into the muscle cells of the animal produces GHRH (Non- GMO) without altering the original gene of the cell. Thus, the produced GHRH has beneficial effects by regulating the metabolism and immune system, and since the concentration of GHRH in the body is always regulated by the animal’s system, there are no adverse effects. The effect only lasts until normal cell turnover replaces the injected plasmid with new cell muscles.

    PLS-D1000 encodes DNA sequence for dog specific growth hormone releasing hormone(GHRH) to stimulate dog’s own GH and IGF-I

    The IGF-I then reactivate diminished thymus function, hematopoiesis, and immune cell function in senior dogs, inducing Increase in T cell production in senior dogs

    A single treatment of PLS-D1000 to senior dogs aims to improve T cell production, appetite, & activities.





  • Growth Hormone Releasing Hormone is one of the naturally occurring hormones in the body and plays an important role not only in the growth of the organism, but also in the regulation of the metabolism and immune system.
    We are developing therapeutic agents using GHRH DNA plasmids, which are designed to be optimal for each animal species. Injecting GHRH DNA into the muscle cells of the animal produces GHRH (Non- GMO) without altering the original gene of the cell. Thus, the produced GHRH has beneficial effects by regulating the metabolism and immune system, and since the concentration of GHRH in the body is always regulated by the animal’s system, there are no adverse effects. The effect only lasts until normal cell turnover replaces the injected plasmid with new cell muscles.

    Immune-modulator “LifeTide®SW5” focuses on supplying the world’s most consumed meats with the highest quality and the safest standards: Pork and Beef.
    Our products are the only NON-GMO therapy in the world approved by the Australian and New Zealand governments. There are no side effects and are proved to be harmless to the human body when ingested. Furthermore, our product offers new opportunities in the pork market by providing high quality pork meat and increasing the productivity of farm through the reduction of pork days to market.